2006 INFINITI M45

4.5L V8FWDAUTOMATICgas
5-Year Cost of Ownership
$69,564 maintenance + known platform issues
~$13,913/yr · 1,160¢/mile equivalent · $37,703 maintenance + $10,111 expected platform issues
Common Problems & Known Issues

The 2006 M45 pairs Infiniti's VK45DE V8 with a 5-speed automatic in a luxury sport sedan package. While the platform is solid, this generation suffers from catastrophic engine failures due to gallery gasket defects and transmission cooler failures that can destroy both the engine and trans.

Gallery Gasket Failure Leading to Engine Destruction

Common · high severity
Typical onset: 60,000-120,000 mi
Symptoms: Low oil pressure warning at idle when hot, Ticking/knocking from valve train especially on cold starts, Oil consumption increases suddenly, Check engine light with oil pressure codes P0524 or P0521, Complete engine seizure in severe cases
Fix: The VK45DE uses porous paper gallery gaskets that disintegrate, starving the top end of oil. Requires engine removal, complete tear-down, replacement of all gallery gaskets with updated metal versions, new timing components, and often machine work if bearings are scored. 30-40 labor hours for proper rebuild with updated gaskets.
Estimated cost: $6,000-12,000

Transmission Oil Cooler Failure Contaminating Both Systems

Common · high severity
Typical onset: 70,000-130,000 mi
Symptoms: Milky or strawberry-colored transmission fluid, Engine coolant level drops without visible leaks, Transmission slipping or delayed engagement, Engine overheating and rough idle, Trans fails to shift properly after coolant intrusion
Fix: The internal transmission cooler in the radiator fails, allowing coolant into the trans and trans fluid into the cooling system. Requires radiator replacement, complete transmission fluid system flush (multiple cycles), external trans cooler installation, and often transmission rebuild if contamination went undetected. If caught early: 8-10 hours. If trans damaged: add 20-25 hours for rebuild.
Estimated cost: $1,500-3,000 early catch, $4,500-7,500 with trans rebuild

Valve Body and Solenoid Issues in RE5R05A Transmission

Occasional · medium severity
Typical onset: 80,000-150,000 mi
Symptoms: Harsh 2-3 or 3-4 shifts, Flare on upshifts (RPM spikes before catching), Slipping in 5th gear on highway, Check engine light with P0745 or P0730 codes, Limp mode activation
Fix: The Jatco RE5R05A develops worn valve body bores and failing pressure control solenoids. Requires transmission removal, valve body replacement or rebuild with updated parts, solenoid pack replacement, and complete fluid service. 12-15 hours labor.
Estimated cost: $2,200-3,800

Front Lower Control Arm Bushing Failure

Common · medium severity
Typical onset: 60,000-100,000 mi
Symptoms: Clunking from front suspension over bumps, Steering wander and poor highway tracking, Uneven inner tire wear, Vibration through steering wheel at highway speeds, Failed state inspection for play in suspension
Fix: The front lower control arm bushings deteriorate and separate, causing alignment issues and handling problems. Most shops replace the entire control arm assemblies rather than pressing new bushings. Both sides typically need replacement simultaneously. 3-4 hours labor plus alignment.
Estimated cost: $800-1,400

VVEL System Actuator and Sensor Failures

Occasional · medium severity
Typical onset: 90,000-140,000 mi
Symptoms: Check engine light with P1084 or P1086 codes, Reduced power and sluggish acceleration, Rough idle especially when cold, Engine runs but feels like it's on 6 cylinders, Increased fuel consumption
Fix: Variable Valve Event and Lift system actuators seize or sensors fail. Requires replacement of actuator motor or position sensors on affected bank. Access requires intake manifold removal. 6-8 hours labor per bank if actuator replacement needed.
Estimated cost: $1,200-2,500

Fuel Pump and Sending Unit Assembly Failure

Occasional · medium severity
Typical onset: 80,000-140,000 mi
Symptoms: Inaccurate fuel gauge reading (stuck or erratic), Hard starting after sitting overnight, Engine stumble or hesitation under acceleration, Fuel pump whine audible from rear seat area, Stalling when fuel tank below 1/4 full
Fix: The in-tank fuel pump assembly develops failing check valves, worn pump motors, or corroded sending unit contacts. Requires fuel tank drop and complete pump assembly replacement. 4-5 hours labor.
Estimated cost: $800-1,400
Owner tips
  • Install an external transmission cooler immediately if not already present—this prevents the radiator cooler failure from destroying the transmission
  • Check transmission fluid color every oil change; pink/red is good, milky/brown means cooler failure is happening
  • Use only Nissan/Infiniti Matic-S transmission fluid; aftermarket substitutes accelerate valve body wear
  • Monitor oil pressure closely—any drop at hot idle is gallery gasket failure beginning
  • Budget $1,500-2,000 annually for deferred maintenance issues on any example over 100k miles
Avoid unless under 60k miles with impeccable service records and external trans cooler already installed—the gallery gasket and trans cooler failures are financially catastrophic and nearly inevitable.
AI-assisted summary drawn from NHTSA recall data, our labor-times database, and platform knowledge. Not a substitute for a pre-purchase inspection on a specific vehicle.
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